Causes
There is a strong genetic link to the causation of AS. There is a mutation on the x chromosome located on either NLGN3 or NLGN4 causing a termination of a protein ( Jamain, Quach, Betancur &Colineaux, 2007). Males are more commonly diagnosed with Aspergers since they only have one x chromosome that has a greater chance to be affected.
What is going on in the brain?
The brain of an individual who has Aspergers syndrome has connectively problems between the hemispheres. Which impacts the cognitive and neurological functions in the frontal lobe (Williams & Minshew, 2007) and the limbic system (Wills, Cabanlit, Bennett, Ashwood, Amaral & Water, 2007). In the frontal lobe the thinking process is impaired instead of prior thinking to make a big decision, those with AS run on impulses. It is about the here and now instead of the affects in to the future from the present. In the brain there seems to be a abnormal size and density of neurons located in the limbic system (Schultz, Romanski & Tsatsanis, 2000).
Wiring
![Picture](/uploads/4/6/8/4/46849839/7207041.jpg?307)
There is strong linkage between defects in dopamine and serotonin when it comes to the transporter system, uptake in the receptors (Pitt, 2014). This can affect the entire wiring of the brain which is believed to be the main causation Aspergers.